The bioengineered tooth, which was grown in place of a lost molar, has the same properties of the old tooth and is strong enough to allow the mouse to chew food normally.
To create the new tooth, the researchers — led by Tokyo University of Science professor Takashi Tsuji — took epithelial cells and mesenchymal cells (about 50,000 each) from a mouse embryo and cultivated them together in a collagen-based medium to create a tiny tooth bud — a mass of tissue that has the potential to develop into a tooth.
They then implanted the 0.5-mm tooth bud into the jawbone of an adult mouse in place of a lost tooth.
After 37 days, a new tooth sprouted, and after 50 days, it had grown to the same height as the adjacent teeth.
The bioengineered tooth has the same hardness as ordinary teeth and it contains blood vessels and nerves, making it sensitive to external stimuli and pain, according to the researchers.
This research is expected to advance the development of “tooth regenerative therapy,” which may one day allow doctors to replace diseased or damaged teeth with bioengineered teeth grown from stem cells such as induced pluripotent stem (iPS) cells.This type of treatment could ultimately eliminate the need for dentures and false teeth.
2 comments:
Is this available for humans now?
Wow! This post is so amazing! Truly, dentistry nowadays has gotten more and more innovated. There are now a lot of ways to replace those false teeth. In Raleigh, dentists would really prefer their clients to have implants instead of dentures because it really look natural on you and have more advantages than ordinary dentures. Raleigh, NC dentist will give a lot of options for us to choose from just to have the smile of our dreams.
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